Advice First Time Arriving in Prague - Any Tips?

I'm arriving solo in Prague via the main train station, Praha hl.n., and planning to walk to my hotel. It's my first time in the city, and I'm a bit nervous about navigating the area, especially with luggage. Does anyone have tips on the best route to take, things to watch out for, or any must-see spots along the way? Also, how safe is the area around the train station for a solo traveler? Any advice would be greatly appreciated!